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Ritonavir or lopinavir/ritonavir greatly maximize plasma concentrations of oxycodone in healthier human volunteers as a consequence of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin drastically decreases plasma concentrations of oxycodone as a result of strong induction of CYP3A4.A comprehensive client record must be taken to doc concomitant medic
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